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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2008 Jul;7(7):1789–1796. doi: 10.1158/1535-7163.MCT-08-0124

Figure 5. Effects of thymoquinone on VEGFR2 activation and signaling pathways.

Figure 5

A, Thymoquinone has little effect of the activation of VEGFR2. B, Effects of thymoquinone on VEGF dependent ERK activation. C, Thymoquinone induces the levels of cleaved caspase 3 and the increased levels of cleaved PARP by thymoquinone are independent of VEGF in HUVECs. HUVECs were treated with thymoquinone at the indicated concentrations for 24 hours and whole cell proteins were performed western blotting. 4 ng/ml VEGF was used in the PARP cleavage assay. D, Thymoquinone inhibited that activation of AKT at 20-40 nM. HUVECs were treated with indicated amount of thymoquinone for 5 minutes.