Table 3.

Plasma and tissue β-carotene concentrations of wild type, heterozygous and homozygous BCMO1-deficient mice. Numbers represent mean ± SD from 4–5 animals/group. β-carotene was not detected at the baseline (6 weeks of age) in any of the mice examined. ND, not detected.

	Male			Female
	Baseline	4 weeks	7 weeks	Baseline	4 weeks	7 weeks
Plasma (μM)
WT	ND	ND	ND	ND	ND	ND
Het	ND	ND	0.02 ± 0.1	ND	ND	ND
KO	ND	0.21 ± 0.1	0.56 ± 0.8	ND	0.21 ± 0.1	0.22 ± 0.1
Liver (ng/g tissue)
WT	ND	94.06 ± 188.1	90.41 ± 202.2	ND	181.04 ± 209.1	ND
Het	ND	211.57 ± 199.3	96.31 ± 215.3	ND	210.60 ± 249.3	102.6 ± 229.4
KO	ND	578.92 ± 154.8	770.32 ± 392.4	ND	967.94 ± 552.7	2152.9±1573.8
Kidney (ng/g tissue)
WT	ND	3.38 ± 6.8	ND	ND	4.60 ± 9.2	ND
Het	ND	9.90 ± 9.0	7.67 ± 8.2	ND	21.99 ± 1.1	8.24 ± 11.4
KO	ND	83.68 ± 48.4	130.95 ± 60.2	ND	236.65 ± 200.0	156.13 ± 137.8
Lung (ng/g tissue)
WT	ND	ND	54.37 ± 121.6	ND	ND	ND
Het	ND	ND	141.41 ± 193.7	ND	ND	ND
KO	ND	ND	326.70 ± 192.2	ND	ND	423.04 ± 113.2
Intestine (ng/g tissue)
WT	ND	66.54 ± 47.0	36.74 ± 21.7	ND	47.02 ± 16.8	18.06 ± 31.3
Het	ND	88.63 ± 91.1	61.98 ± 41.2	ND	25.45 ± 17.1	21.88 ± 20.3
KO	ND	225.98 ± 202.9	107.49 ± 84.1	ND	103.01 ± 42.9	58.84 ± 4.0
Testes (ng/g tissue)				Ovaries (ng/g tissue)
WT	ND	ND	ND	ND	ND	ND
Het	ND	5.43 ± 12.1	27.39 ± 18.5	ND	ND	ND
KO	ND	98.14 ± 49.3	493.05 ± 451.0	ND	573.63 ± 152.8	1122.2 ± 935.0
Epididymal fat (ng/g tissue)				Periuterine fat (ng/g tissue)
WT	ND	ND	ND	ND	ND	ND
Het	ND	ND	ND	ND	ND	ND
KO	ND	128.65 ± 112.4	226.38 ± 45.1	ND	333.52 ± 143.9	638.84 ± 66.4
Retroperitoneal fat (ng/g tissue)
WT	ND	ND	ND	ND	ND	ND
Het	ND	ND	ND	ND	ND	ND
KO	ND	217.43 ± 20.0	325.47 ± 211.1	ND	406.92 ± 224.3	659.66 ± 93.5
Inguinal fat (ng/g tissue)
WT	ND	ND	ND	ND	ND	ND
Het	ND	ND	ND	ND	ND	ND
KO	ND	163.49 ± 157.6	340.46 ± 54.5	ND	389.55 ± 198.2	989.91 ± 462.8