Table 1.
Drugs associated with QT prolongation/Torsade de pointes grouped according to major class1
| Anti-infective | Antipsychotic/psychiatric | Cardiovascular | Miscellaneous | ||||
|---|---|---|---|---|---|---|---|
| Amantadine (2) | antiviral | Chlorpromazine (1) | antipsychotic | Amiodarone (1) | antiarrhythmic | Alfuzosin (2) | alpha1-antagonist |
| Azithromycin (2) | macrolide | Clozapine (2) | Bepridil (1) | CCA2 | Arsenic trioxide (1) | anti-neoplastic | |
| Clarithromycin (1) | Droperidol (1) | Disopyramide (1) | antiarrhythmic | Chloral hydrate (2) | Sedative | ||
| Erythromycin (1) | Haloperidol (1) | Dofetilide (1) | Felbamate (2) | antiepileptic | |||
| Foscarnet (2) | antiviral | Lithium (2) | mood stabilizing | Flecainide (2) | Fosphenytoin (2) | antiepileptic | |
| Gatifloxacin (2) | quinolone | Mesoridazone (1) | antipsychotic | Ibutilide (1) | Indapamide (2) | diuretic (thiazide) | |
| Gemifloxacin (2) | Paliperidone (2) | Isradipine (2) | CCA2 | Levomethadyl (1) | opiate agonist | ||
| Halofantrine (1) | anti-malarial | Pimozide (1) | Moexipril/HCTZ (2) | anti-hypertensive | Methadone (1) | opiate agonist | |
| Hydroxychloroquine (1) | anti-protazoal | Quetiapine (2) | Nicardipine (2) | CCA2 | Octreotide (2) | somatostatin analogue | |
| Levofloxacin (2) | quinolone | Risperidone (2) | Procainamide (1) | antiarrhythmic | Perflutren liquid microspheres (2) | Cardiac echo contrast agent | |
| Moxifloxacin (2) | Thioridazine (1) | Qunidine (1) | |||||
| Ofloxacin (2) | Venlafaxine (1) | antidepressant | Ranolazine (2) | Tacrolimus (2) | immunosuppressant | ||
| Pentamidine (1) | anti-protazoal | Ziprasidone (2) | antipsychotic | Sotalol (1) | Tamoxifen (2) | estrogen antagonist | |
| Sparfloxacin (1) | quinolone | Tizanidine (2) | alpha2-agonist | ||||
| Telithromycin (2) | ketolide | Anti-emetics | Salmeterol (2) | beta2-adrenergic agonist | |||
| Voriconazole (2) | triazole | Dolasetron (2) | serotonin | Sunitinib (2) | anti-neoplastic | ||
| Granisetron (2) | receptor | Vardenafil (2) | phosphodiesterase inhibitor | ||||
| Odansetron (2) | antagonist | ||||||
1
Numbers in parentheses correspond to likelihood that the agent is associated with torsade de pointes according to the Center for Therapeutics and Research (CERT) (4) (accessed April 2008). A ranking of '1' denotes drugs that are generally accepted to have a risk of causing torsades de pointes while '2' denotes drugs that have reported association with torsades de pointes but for which substantial evidence is lacking. Drugs not availible in the US (i.e., astemizole, cisapride, domperidone, probucol, roxythromycin, terfenadine) are excluded.
2
CCA - Calcium channel antagonist