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. Author manuscript; available in PMC: 2008 Nov 25.
Published in final edited form as: J Neurosci Methods. 2007 Jun 30;166(1):116–124. doi: 10.1016/j.jneumeth.2007.06.018

Figure 7.

Figure 7

Analysis of Schmidt-Lantermann incisures (clefts). A. Schmidt-Lantermann incisures, which are often attributed to compression injury, appear as concentric layers of myelin with an interposed layer of myelin lamina. B. For standard histomorphometric analysis, the inner myelin ring is used for measures of myelin thickness, as this maintains the original axon-myelin relationship. C. Threshold adjustment can be used to identify Schmidt-Lanterman clefts for specific study of this histopathological entity. Conventional image analysis systems will fail to identify these clefts, and as result the average myelin thickness is distorted due to overestimation of myelination among fibers with these incisures.