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. Author manuscript; available in PMC: 2008 Dec 20.
Published in final edited form as: Science. 2008 Jun 20;320(5883):1643–1647. doi: 10.1126/science.1155390

Figure 1. Reduced relative expression of extended 3′ UTR regions 48h after T lymphocyte activation.

Figure 1

(A) Scatter plot of common and extended UTR region expression of tandem APA genes in resting and stimulated (48h) T lymphocytes. Significantly increased expression of isoforms resulting from distal PAS (blue) or proximal PAS (red) (P < 0.02, 20% FDR) are colored. Inset: Direction of change (13 distal, 86 proximal; P < 2.3×10-14, binomial test). (B) Relative expression of mutually exclusive 3′ exons in resting and stimulated (48h) T lymphocytes. Significant events (P < 0.0031; 5% FDR) and inset are as in (A). (C) Expression of common versus extended 3′ UTR regions in resting (0h, n = 1768) versus activated (48h, n = 1761) cells. Difference P < 6.6×10-19, t-test. (D) Relative expression (activated/resting) of all tandem UTR genes and in the set of significant events from (A) after stimulation.