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. 2008 Jul 11;19(8):763–773. doi: 10.1089/hum.2007.059

FIG. 1.

FIG. 1.

Bioluminescence imaging of C57BL/6J mice administered DNA encoding the luciferase gene. C57BL/6J mice (two per group) were intradermally administered two bullets containing 1 μg of plasmid DNA, each encoding luciferase (pcDNA3-Luc) or control (pcDNA3), via gene gun and luciferase activity was monitored over a period of 5 days by bioluminescence imaging. (A) Representative luminescence images demonstrating in vivo luciferase expression 30 min after gene gun administration in luciferase DNA-administered mice (left) and control DNA-administered mice (right). (B) Bar graph of luminescence intensity over a period of 144 hr after gene gun administration. Results are expressed as means and SD. Note: Luciferase activity peaked 24 hr postadministration and then gradually declined.