Table 1.
Characterization of dendrimer nanodevices
# | Functional Groups | # of groups measured by potentiometry | # of groups measured by SEC | # of groups measured by MALDI | Mass measured by SEC | Mass measured by MALDI* |
---|---|---|---|---|---|---|
1 | NH2 | 119 | -------- | -------- | 27180 | 26572 |
2 | NHAc | 72 | 51 | 55 | 29300 | 28887 |
3 | NHBT | 8 | 5 | 6 | 30530 | 30369 |
4 | NHSAH | 39 | 11 | 10 | 31650 | 31416 |
5 | NHSAcRGD | ---------- | 4 | 2 | 34110 | 32691 |
1 - PAMAM_E5.(NH2)119 (starting material); 2 - PAMAM_E5.(NHAc)72(NH2)47 (partially acetylated derivative); 3 - PAMAM_E5.(NHAc)72(NHB)8(NH2)39 (biotinylated and partially acetylated derivative); 4 - PAMAM_E5.(NHAc)72(NHB)8(NHSAH)39 (partially acetylated, biotinylated and succinaminated compound); 5 - PAMAM_E5.(NHAc)72(NHB)8(NHSAH)35(NHSAcRGD)4 (cRGD peptides conjugated to compound, for short RGD targeted and biotinylated nanodevice.
Molecular mass of the highest frequency fragment in the major peak on Figure 2.