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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Arch Gen Psychiatry. 2008 Feb;65(2):179–188. doi: 10.1001/archgenpsychiatry.2007.19

Figure 3.

Figure 3

Summary of functional connectivity findings. A, Red denotes regions of interest (ROIs) with significantly lower correlations in patients with major depressive disorder (MDD) than comparison subjects between current density within the rostral anterior cingulate cortex (ACC) and medial prefrontal cortex (PFC) cluster 80 milliseconds after error (Figure 2C) and the current density at the late error positivity global field power peak (472 milliseconds). The only ROI showing group differences in functional connectivity was the left dorsolateral PFC cluster shown in red (Brodmann area 8/9; 12 voxels; P<.005; peak voxel Montreal Neurologic Institute coordinates: x=−24, y=38, z=36). Blue represents the homologous right dorsolateral PFC cluster, which was used to formally evaluate laterality. L indicates left; R, right. B and C, Scatterplots of the current density (averaged across voxels) within the rostral ACC and medial PFC cluster 80 milliseconds after committing an error and the late error positivity (472 milliseconds) in the left dorsolateral PFC ROI for the comparison subjects (B) (r=0.69; P=.001) and patients with MDD (C) (r=−0.46; P=.06).