Table 2.
Behavioral, scalp ERP, and LORETA findings
MDD Subjects | Comparison Subjects | Group Effects | ||||
---|---|---|---|---|---|---|
Mean | SD | Mean | SD | p-valuea | ||
A. Behavioral Datab | ||||||
Post-correct accuracy | 0.91 | 0.08 | 0.92 | 0.05 | n.s. | |
Post-error accuracy | 0.87 | 0.08 | 0.92 | 0.06 | 0.005 | |
|
||||||
Post-correct RT | 340.12 | 82.29 | 322.34 | 54.40 | n.s. | |
Post-error RT | 380.95 | 97.21 | 354.89 | 68.23 | n.s. | |
B. Scalp ERP data (μV)c
| ||||||
ERN | −2.74 | 1.83 | −1.42 | 1.69 | 0.01 | |
CRN | 0.20 | 1.80 | 1.33 | 2.01 | n.s. | |
|
||||||
Early Pe | 3.58 | 2.33 | 3.42 | 2.40 | n.s. | |
Late Pe | 3.61 | 2.40 | 4.29 | 3.52 | n.s. | |
C. LORETA datad
| ||||||
rACC (BA 32) | −3.50 | 0.09 | −3.74 | 0.18 | 0.00003 |
Abbreviations: ACC, anterior cingulate cortex; BA, Brodmann area; CRN, correct-response negativity; ERN, error-related negativity; ERP, event-related potential; LORETA, low-resolution electromagnetic tomography; MDD, major depressive disorder; Pe, error positivity; RT, reaction time.
Data are presented as mean (SD).
Findings from unpaired t tests (postcorrect RT, posterror RT, early PE, and late PE) or post hoc Newman-Keuls tests (postcorrect accuracy, posterror accuracy, ERN, and CRN) are reported.
Posterior adjustment effects were restricted to trials following incongruent trials. Comparison subjects: n=20; patients with MDD: n=20.
Mean amplitudes (averaged across Fz, FCz, Cz, and Pz) for incongruent trials. Comparison subjects: n=18; patients with MDD: n=18.
Current density, 80 milliseconds after error for incongruent trials. Comparison subjects: n=18; patients with MDD: n=18.