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Blocking mTOR with CCI-779 correlates with down-regulation of HIF-1α and increased sensitivity to 2-DG. (A, B) Under hypoxia CCI-779 increased the cytotoxicity of 2-DG in SCLC line B which expresses high levels of pmTOR but not in NSCLC line A which expresses low levels of pmTOR. Each data point is the average of triplicate samples with S.D. *P=0.002, **P=0.004
