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In cells unable to mount a HIF response, CCI-779 increases resistance to 2-DG which correlates with increased ATP levels. (A, B) ATP assays in NSCLCA and C4 cells after exposure to various doses of 2-DG and 0.1μg/nl of CCI-779 under hypoxic conditions for 24h. Note the increase in ATP levels in both (A) NSCLC line A and (B) hepatoma (HIF−) cell line, C4, after treatment with CCI-779. Each data point is the average of triplicate samples with S.D. P<0.05.
