Fig. 3.
Significant suppression of glial cell activation in GMF-KO mice infused with amyloid beta. Intracerebro-ventricular infusion of Aβ1-42 was for four weeks using a micro-osmotic pump (Alzet). At post-operative day 28, activated GFAP-positive astrocytes (A) and F4/80-positive microglia (B) in the hippocampus were measured (n= 5 mice per group). Representative micrographs of GFAP-positive astrocytes (C) and F4/80-positive microglia (D) in Aβ-infused GMF-KO and Wt are shown (X40 magnification). * Vehical-infused Vs Aβ-infused. # Aβ-infused Wt Vs Aβ-infused GMF-KO. (p< 0.05)