Fig. 5.
Reduced expressions of inflammatory cytokine/chemokine in primary cultures of GMF-KO astrocytes (A & B) and microglia (C & D) compared to Wt glial cells and return of increased levels in GMF-KO cells reconstituted to over express GMF with an adenoviral GMF construct. Cells were treated with 15 µM Aβ1-42 (oligomeric and fibrillar) for 24 h and levels of cytokine/chemokine were measured by ELISA. Note significant difference between oligomeric and fibrillar Aβ. (p< 0.05)