Fig. 9.

T-maze training for simple position discrimination, showing learning curves for Wt (A) and GMF-KO (B) mice following vehicle and Aβ infusion (28 days). GMF-KO group consisted of 12 mice, and the Wt group, 14 mice. Values are mean of each group for each day (±S.E.M.). Logistic regression analysis using the method of generalized estimating equations (GEE) was use to compare the mean % correct response between the two groups. The data for this analysis was the number of correct responses out of 10 attempts repeated over 11 days. A logistic model was employed because the outcome variable has a binomial distribution with the GEE method used to account for the correlation of repeated measures from the same mouse.