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. Author manuscript; available in PMC: 2009 Jul 15.
Published in final edited form as: J Immunol. 2008 Jul 15;181(2):1299–1306. doi: 10.4049/jimmunol.181.2.1299

Figure 1. The nucleotide mutation pattern in productive and nonproductive heavy chain rearrangements in AICDA−/− B cells.

Figure 1

The individual nucleotide substitutions detected in the variable segment of (A) nonproductive VHDJH and (B) productive VHDJH rearrangements in peripheral blood B cells from 4 normal donors and 3 AICDA−/− patients are presented. The percentages of all mutations (lower panels in each group) are scored after correction for base composition of the target sequence. Transitions appear in bold face type. *Significant (p=0.03) difference between AICDA−/− and normal donors; †significant (p<0.0001) difference between transitions and transversions and significant (p<0.0008) difference in transitions between AICDA−/− and normal donor.