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. Author manuscript; available in PMC: 2009 Jul 15.
Published in final edited form as: J Immunol. 2008 Jul 15;181(2):1299–1306. doi: 10.4049/jimmunol.181.2.1299

Figure 2. The nucleotide mutation pattern in nonproductive light chain rearrangements in AICDA−/− B cells.

Figure 2

The light chain data is collected from AICDA−/− patients P4 and P5 and consists of 18 mutations from 294 nonproductive kappa rearrangements and 16 mutations from 142 nonproductive lambda rearrangements. (A) Individual nucleotide substitutions in the light chain repertoires are presented in which the percentage of all mutations (lower panels) are scored after correction for base composition of the target sequence. (B) The mutation frequency of a specific nucleotide inside vs outside a hypermutable motif was calculated as shown in Table 3. *Significant (p=.02) difference between AICDA−/− and normal donors; †significant (p<.0001) difference between transitions and transversions and significant (p=.0008) difference in transitions between AICDA−/− and normal donor.