. Author manuscript; available in PMC: 2009 Jul 15.

Published in final edited form as: J Immunol. 2008 Jul 15;181(2):1299–1306. doi: 10.4049/jimmunol.181.2.1299

Table I.

Mutation frequency of VH segment of AICDA deficient B cells

	AICDA^−/−		Normal Donors
	NP	P	NP	P
Total number of Rearrangements	320	1150	105	636
Total number of Mutations	43	124	627	4864
Percentage of Sequences Mutated	39/320^*	104/1150^*	76/105	479/636
Percentage of Sequences Mutated	12%	9%	71%	75%
Mutation Range	1−2	1−4	1−33	1−38
Mutation Frequency Overall	43/64081^*	124/230514^*	627/22693	4864/152977
Mutation Frequency Overall	0.07%	0.05%	2.8%	3.2%
Mutation Frequency of Mutated	43/7799^*	124/19938^*	627/15149	4864/113434
Rearrangements	0.6%	0.6%	4.1%	4.3%

NP = nonproductive rearrangements, P = productive rearrangements. The AICDA^−/− data includes CD19⁺CD27⁻ and CD19⁺CD27⁺ sequences from three patients. The control data comes from previous reports of 4 individuals and three different experiments that collected IgM⁺, IgM⁺CD5⁺, IgM⁺CD5⁻, IgD⁺CD27⁻ and IgD⁻CD27⁺ B cells which represent normal unmutated and mutated populations in peripheral blood. The mutation frequencies were calculated from the number of mutations/total number of bases analyzed or from the total number of bases analyzed from mutated sequences only.

Significant (p<.0001) difference between AICDA^−/− and normal donors.