. Author manuscript; available in PMC: 2010 Jan 25.

Published in final edited form as: Tetrahedron Asymmetry. 2009 Jan 25;19(14):1714. doi: 10.1016/j.tetasy.2008.06.010

Table 2.

Lipase-catalyzed kinetic resolution of amino esters rac-6a–b using carbonates 4a–b (ratio 1:2.5) in TBME

Entry	Enzyme	R¹	R²	T (°C)	t (h)	ee_P (%)^a	ee_S (%)^a	c (%)^b	E^c
1	CAL-A Codexis	Me	3-MeO-C₆H₄	30	23.5	----	----	100	----
2	CAL-A Codexis	Me	CH₂=CHCH₂	30	23	>99	25	20	>200
3	CAL-A Codexis	Me	CH₂=CHCH₂	45	48	>99	13	12	>200
4	CAL-A Codexis	Bn	CH₂=CHCH₂	30	57	88	>99	53	121
5	CAL-A Biocatalytics	Bn	CH₂=CHCH₂	30	72	98 (91)^d	>99 (90)^d	50	>200

Calculated by HPLC

c = ee_S/(ee_S+ee_p)

E = ln[(1−c)×(1−ee_P)]/ln[(1−c)×(1+ee_P)]

Isolated yields in brackets.