(A) Decreased expression of markers of alternative activation in IL-4-stimulated PPARδ −/− BMDM. Relative expression of alternative activation mRNAs was quantified using by qRT-PCR. Retnla, resistin-like a; Mrc1, mannose receptor; Chi3l3, chitinase 3-like 3; Pdcd1lg2, programmed cell death 1 ligand 2. (B, C) PPARδ is required for suppression of IL-6 and IL-12 production in alternatively activated BMDMs. (D) PPARδ is required for the mitogenic response to IL-4 in BMDMs. Data presented as mean ± s.e.m. *P < 0.05, **P < 0.01.