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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Cell Metab. 2008 Jun;7(6):496–507. doi: 10.1016/j.cmet.2008.04.003

Figure 2. PPARδ is required for expression of the immune phenotype of alternative macrophage activation.

Figure 2

(A) Decreased expression of markers of alternative activation in IL-4-stimulated PPARδ −/− BMDM. Relative expression of alternative activation mRNAs was quantified using by qRT-PCR. Retnla, resistin-like a; Mrc1, mannose receptor; Chi3l3, chitinase 3-like 3; Pdcd1lg2, programmed cell death 1 ligand 2. (B, C) PPARδ is required for suppression of IL-6 and IL-12 production in alternatively activated BMDMs. (D) PPARδ is required for the mitogenic response to IL-4 in BMDMs. Data presented as mean ± s.e.m. *P < 0.05, **P < 0.01.