Skip to main content
. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Cell Metab. 2008 Jun;7(6):496–507. doi: 10.1016/j.cmet.2008.04.003

Figure 3. Conjugated oleic acid potentiates alternative macrophage activation.

Figure 3

(A) Oleic acid potentiates IL-4 induction of arginase activity in wild type, but not PPARδ−/− BMDM. (B–E) PPARδ is required for potentiation of alternative activation by oleic acid. BMDMs from 129/SvJ wild type and PPARδ null mice were stimulated IL-4 for 48 hours in the presence of BSA or BSA:oleic acid conjugate. qRT-PCR analysis were performed on mRNAs for Arg1 (arginase I), Clec7a (dectin-1), Pdcd1lg2 (programmed cell death 1 ligand 2), and Chi3l3 (chitinase 3-like 3). Data presented as mean ± s.e.m. *P < 0.05, **P < 0.01.