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. Author manuscript; available in PMC: 2009 Nov 15.
Published in final edited form as: J Neurosci Res. 2008 Nov 15;86(15):3382–3392. doi: 10.1002/jnr.21793

Figure 6.

Figure 6

Application of BDNF siRNA to cut axons has no effect on TrkB mRNA. A. Real-time PCR of retinas shows that axotomy and PBS treatment increase TrkB mRNA levels at 48 h and 1 week after axotomy. FGF-2 treatment of the cut axons doubles this increase, at 48 h only. Neither BDNF nor negative control siRNA has any significant effect upon the increases in TrkB mRNA induced by axotomy or by FGF-2. B. In situ hybridization shows TrkB mRNA in RGCs at 48 h after axotomy and FGF-2 treatment. C. SiRNA application has no effect on TrkB mRNA in RGCs. Scale bar in B: 30 μm.