Table 3.
The relationship of ITGB3 polymorphisms with platelet αIIbβ3 receptor density, plasma fibrinogen and plasma vWF activity
| −468 G/A | −425 A/C | −400 C/A | Leu33Pro | |||||
|---|---|---|---|---|---|---|---|---|
| mean (95% CI) | p | mean (95% CI) | p | mean (95% CI) | p | mean (95% CI) | p | |
| αIIbβ3 | GG: 136 (133, 139) | 0.12 | AA: 136 (133, 139) | 0.85 | CC: 137 (134, 140) | 0.62 | LL: 137 (134, 140) | 0.97 |
| (MFI) | GA: 139 (134, 143) | AC: 138 (133, 143) | CA: 237 (132, 142) | LP: 136 (131, 141) | ||||
| AA: 126 (119, 133) | CC: 138 (131, 144) | AA: 128 (120, 137) | PP: 138 (133, 143) | |||||
| Fibrinogen | GG: 3.36 (3.21, 3.52) | 0.62 | AA: 3.36 (3.21, 3.51) | 0.33 | CC: 3.40 (3.26, 3.55) | 0.92 | LL: 3.35 (3.20, 3.50) | 0.17 |
| (gL−1) | GA: 3.51 (3.24, 3.80) | AC: 3.60 (3.29, 3.94) | CA: 3.43 (3.14, 3.74) | LP: 3.68 (3.36, 4.02) | ||||
| AA: 3.40 (3.06, 3.78) | CC: 3.35 (2.60, 4.31) | AA: 3.58 (3.30, 3.90) | PP: 3.32 (2.67, 4.12) | |||||
| vWF | GG: 112.7 (105.1, 120.4) | 0.47 | AA: 105.4 (99.6, 111.2) | 0.01 | CC: 113.1 (106.0, 120.1) | 0.42 | LL: 106.8 (100.5, 113.2) | 0.06 |
| activity | GA: 108.3 (99.3, 117.3) | AC: 124.4 (110.0, 138.8) | CA: 105.3 (95.2, 115.3) | LP: 121.8 (109.6, 134.0) | ||||
| (%) | AA: 97.1 (76.7, 117.5) | CC: 139.7 (76.9, 202.5) | AA: 99.4 (70.2, 128.7) | PP: 131.6 (73.9, 189.3) |
Data presented as mean or geometric mean (95% confidence intervals)
MFI: Mean fluorescence intensity