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. 2000 May 2;97(10):5598–5603. doi: 10.1073/pnas.100104597

Figure 6.

Figure 6

CTA. Saccharin-flavored water was paired with an i.p. injection of saline (wild type, n = 5; Syt IV mutant, n = 6) or LiCl (wild type, n = 5; Syt IV mutant, n = 6). At 24 h later, all mice were tested for saccharin aversion. Aversion index is calculated as [total saccharin water consumed, in ml]/[total saccharin water, in ml]+ [total unflavored water consumed, in ml]. Columns and error bars represent mean ± SEM, respectively. MANOVA revealed significant main effect of treatment [F (1, 18) = 28; P < 0.0001] in wild-type and Syt IV mutant mice, but no difference in genotype [F (1, 18) = 0.3; P > 0.5] or genotype-by-treatment interaction [F (1, 18) = 0.1; P > 0.9].