Skip to main content
. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Mol Genet Metab. 2008 May 9;94(3):283–286. doi: 10.1016/j.ymgme.2008.03.012

Figure 1.

Figure 1

The aggresome pathway prevents accumulation of misfolded proteins. Unfolded or misfolded protein can originate from translating polysomes, from proteins retrotranslocated from the ER to the cytosol, or from proteins damaged by stress. If such proteins fail to fold correctly and are not degraded by the proteasome, they can form aggregates in cells. These aggregates are transported by the microtubule and require the dynein/dynactin motor complex. HDAC6 (dotted arrow) deacetylates α-tubulin and associates with dynein (dotted arrow) to facilitate transport of aggresomes through the cytosol for degradation. Tubacin and LBH589 are small molecule inhibitors that target HDAC6 or pan HDACs, respectively, resulting in increased acetylation of α-tubulin, accumulation of polyubiquitinated proteins, and apoptosis [25, 31].