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. 2008 Jul 25;47(34):8961–8969. doi: 10.1021/bi800604c

Figure 1.

Figure 1

Sequence conservation at a UBL’s residue 72 and E1 residues corresponding to UBA3’s 190. (A) Sequence alignment of the C-terminal tail region of NEDD8 and ubiquitin (UBIQ) from the following organisms: Hs, human; Mm, M. musculus; AT, A. thaliana; Ce, C. elegans; Dm, D. melanogaster. NEDD8 and ubiquitin residue 72 are highlighted. (B) Sequence alignment of the E1 region containing Arg190 (highlighted) from the UBA3 subunit of NEDD8’s E1 (E1 NEDD8) and the corresponding Gln from the UBA1 ubiquitin E1 (E1 UBIQ). (C) Nomenclature and sequences for NEDD8, ubiquitin, and E1 NEDD8 (APPBP1-UBA3) mutants.