Table 2. TUR plus one immediate instillation followed by short-term versus long-term instillations during 12 mo.

Study	Year	Drug	% single tumors	Recurrence/total no. of patients		p
				Short-term instillations	Long-term instillations (12 mo)
Bouffioux [13]	1995	MMC 30 mg/50 ml	62%	70/160 (43.8%)	67/150 (44.7%)	0.87
		ADM 50 mg/50 ml
Okamura [14]	1998	Epirubicin 40 mg/40 ml	67%	NA/69 (22.8%)	NA/69 (24.9%)	0.62*
				2 yr	2 yr
Koga [15]	2004	Epirubicin 30 mg/30 ml	61%	23/73 (31.5%)	10/77 (13.0%)	0.005*
						0.006

Treatment schedules: reference 13: 9 instillations during 6 mo vs. 15 instillations during 12 mo; reference 14: 6 instillations during 1 mo vs. 17 instillations during 12 mo; reference 15: 9 instillations during 3 mo vs. 19 instillations during 12 mo. TUR = transurethral resection; MMC = mitomycin C; ADM = Adriamycin; NA = not available.

^*Log-rank test.