. Author manuscript; available in PMC: 2009 Jul 18.

Published in final edited form as: Neurosci Lett. 2008 May 16;439(3):269–274. doi: 10.1016/j.neulet.2008.04.104

Table 1.

Comparison of PGC-1α- and forskolin-induced changes in mRNA expression.

		Fold Control
		PGC-1α AdV	Forskolin (5 μM)
Proliferation or differentiation	Cyclin D1	1.1 +/− 0.2	0.6 +/− 0.1 ^*
	MPZ	0.8 +/− 0.1	5.8 +/− 0.8 ^*
	PMP22	0.9 +/− 0.1	3.2 +/− 0.4 ^**
	Laminin	1.2 +/− 0.1	0.8 +/− 0.1
PGC-1α-interacting transcription factors	NRF-1	1.1 +/− 0.1	1.0 +/− 0.1
	ERRα	4.0 +/− 0.6 ^*	0.5 +/− 0.1
Mitochondrial biogenesis and fusion	TFAM	1.4 +/− 0.2	1.2 +/− 0.1
	Mfn1	2.3 +/− 0.3 ^*	2.2 +/− 0.2 ^**
	Mfn2	1.8 +/− 0.1 ^*	0.8 +/− 0.1
Antioxidant enzymes	SOD2	4.9 +/− 0.8 ^**	0.8 +/− 0.1
	GPx	1.2 +/− 0.1	0.8 +/− 0.1

Immature Schwann cells were treated with either GFP or GFP-PGC-1α-expressing adenovirus for 48 hours (MOI: 200:1) or with 5 μM forskolin for 3 days, and RNA was isolated and reverse transcribed for quantitative PCR using Taqman primer/probe sets. Results are grouped by gene function, and data are expressed as fold of GFP or 0 μM forskolin control, with normalization to β-actin. (n=3/group,

p < 0.05,

^**

p < 0.01, T-test).