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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Cell Signal. 2008 May 18;20(9):1616–1624. doi: 10.1016/j.cellsig.2008.05.004

Fig. 6. Effect of βArr2 overexpression on DAMGO- and morphine-induced OPRM1 desensitization in HEK293 cells.

Fig. 6

The abilities of DAMGO to induce the desensitization of wild type OPRM1 and phosphorylation deficient OPRM1(363/370/375) were examined in HEK293 cells transfected with βArr2-FLAG (○) or with mock transfection (■). Cells were pretreated with 100nM DAMGO or morphine for the indicated time. The agonist-induced desensitization rate was calculated as described in the legend of Fig. 2B. Data were showed as the averages of n≥3 experiments in which wild type OPRM1 was pretreated with 100nM DAMGO (panel A) and 100nM morphine (panel C) or OPRM1(363/370/375) was pretreated 100nM DAMGO (panel B) and 100nM morphine (panel D) respectively. * denotes p < 0.05; and ** denotes p< 0.01.

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