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Effect of SM2 deficiency on smooth muscle contraction. (A and B) Representative traces from 5–7 experiments showing the contraction to 60 mM K+ with subsequent 10–50 mM K+ (A) or 1 μM Carbachol (B) in SM+/+ (blue), SM2+/− (green), or/and SM2−/− (red) bladders. (C) Representative traces from 4 experiments showing contraction of SM+/+ (blue) and SM2−/− aortas (red) to submaximal contraction of K+ (30 mM).
