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Antagonist pharmacology of the L-AChR. L-AChRs activated by 100 μM ACh are inhibited by 100 μM dTC (96 ± 1%; n = 7), 10 μM MLA (39 ± 8%; n = 5), and 100 μM Hex (30 ± 2%; n = 5). In contrast, 100 nM α-BgTx and 10 μM DHβE produce only very weak inhibition (7 ± 1%, n = 5; and 6 ± 1%, n = 5; respectively).
