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. 2008 Nov 19;105(47):18079–18080. doi: 10.1073/pnas.0810064105

Fig. 1.

Fig. 1.

Schematic illustration of the gamma-generating EC microcircuit described in Middleton et al.'s study (6). The circuit is composed of 2 subcircuits: the principal cell (Pc)–basket cell (Bc) and the principal cell–goblet cell (Gc) loops. These 2 subcircuits generate mutually exclusive ≈40- and ≈30-Hz gamma oscillations. (Upper) Illustration of the microcircuit. (Lower) Raster plots illustrate the firing of the different cell types during gamma oscillations. (A) Fast (≈40 Hz) gamma oscillations are generated through the recurrent interactions between basket cells and principal cells. Such interaction requires NMDAR-mediated depolarization of basket cells. Basket cells inhibit goblet cells, preventing the activation of the pyramidal cell–goblet cell loop. (B) Slow (≈30 Hz) gamma oscillations are generated similarly by goblet cells and principal cells. In the absence of NMDAR-mediated excitation, the spiking activity of basket cells is reduced, releasing goblet cells to interact with principal cells.