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The incidence of the disease depends on the number of HSCs that are actively contributing to hematopoiesis. The incidence predicted by the model matches the epidemiological data optimally when NSC ≈ 400. As the size of the HSCs increases, the incidence of the disease decreases. In these simulations, the rate of HSC replication was kept constant at ≈1/year because there is no experimental data relating how the rate of replication of HSCs changes as their population increases.
