Fig. 5.

Patients with aplastic anemia (AA) have a higher prevalence of PIG-A mutated SCs. As the size of the stem cell pool decreases as in AA, the prevalence of PIG-A mutants increases. The figure compares the results from Fig. 2 with those obtained by considering a population of 100 or 60 SCs that must replicate at a rate 4 and 6 times faster than normal to maintain hematopoiesis. Under stochastic dynamics and neutral evolution, the clone is more likely to increase in size and appear “more often” in patients with AA.