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. 2008 Dec 12;4(12):e1000236. doi: 10.1371/journal.ppat.1000236

Figure 1. Short-term vaccination against MNV using live MNV strains and VRPs expressing ORF1, ORF2, and ORF3 from MNV and ORF2 from Chiba virus and Lordsdale virus.

Figure 1

(A) Vaccination protocol used in short-term vaccination. Viral titers in (B) distal ileum and (C) MLN of adult (8-week-old) WT mice after MNV1.CW3 challenge following vaccination with the indicated vaccines. Viral titers in (D) distal ileum and (E) MLN of adult (8-week-old) or aged (14-month-old) WT mice immunized with MNV1.CW3 ORF2 VRP or HA VRP and challenged with MNV1.CW3. These data are pooled from two independent experiments with 3-5 mice per group in each experiment. (**) indicates p<0.0001, (*) indicates p<0.05. Unless otherwise stated, live virus vaccinations are compared to vaccination with reovirus, and VRP vaccinations are compared to HA VRP. LD indicates the limit of detection. Bars indicate the arithmetic mean.