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. 2008 Dec 12;4(12):e1000236. doi: 10.1371/journal.ppat.1000236

Figure 7. Immune CD4 and CD8 T cells are both required, and perforin plays a role in clearance of persistent MNV infection in RAG1-/- recipients.

Figure 7

(A) Representative flow cytometric analysis of splenocytes harvested from RAG1-/- recipient mice 6 days post-transfer of splenocytes. Viral titers in (B) duodenum/jejunum and (C) distal ileum 6 days after adoptive transfer of medium alone, WT non-immune splenocytes (N–I), WT immune splenocytes (WT), WT immune splenocytes with or without depleting antibodies or immune splenocytes from IFNγ-/- or perforin-/- (Pfn-/-) mice. These data are pooled from three independent experiments with 3–5 mice per group in each experiment. (**) indicates p<0.0001, (*) indicates p<0.05. LD indicates the limit of detection.