Figure 5.

Rat core temperature and immunofluorescence micrographs from rat caudate-putamen. Rats were injected into the caudate-putamen with phosphorothioate (PS) oligodeoxynucleotides (A), gap-mer DNA/phosphorothioate oligodeoxynucleotides (B), or LNA oligodeoxynucleotides (C), on day 1 and day 3 (10 nmol/day), and core temperature was measured 2 h after last injection. Temperature data are presented as means ± SEM based on three animals per group. A pooled group of DNA-injected animals served as controls (n = 24). Statistical analysis was done by means of an independent Student's t test (^nsP > 0.05, *P < 0.05, **P < 0.01). Fluorescence micrographs from sections stained for tyrosine hydroxylase from caudate-putamen (same rats as used in temperature experiments). Arrow indicates lesion with absence of tyrosine hydroxylase staining. (Scale bar, as shown in A, = 100 μm) (CPu, caudate-putamen; cc, corpus callosum)