Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Top: Example of a linear binding motif bound to its substrate. CtIP phosphopeptide is bound to BRCT repeats of BRCA1 (1Y98). Bottom: Model of a binding motif. The motif, with sequence RWWLY, is designed to bind specifically to the substrate. The yellow residues are hydrophobic, the blue negatively charged, the red positively charged and the grey hydrophilic.
