Figure 2. Average disorder of the available Mediator subunits in Saccharomyces cerevisiae (grey) and in Homo sapiens (crosshatched) as computed by the IUPred algorithm [26].

0.5 (dashed line) is the threshold for disordered state and 0.4 (dotted line) is the average disorder of all disordered segments in the DisProt database [29]. Subunits belonging to the different modules (Head, Middle, Tail, Cdk) are separated by vertical lines.