Figure 3.

The α_2A adrenergic receptor, D_2S dopaminergic receptor, and M₄ muscarinic receptor exhibit different coupling profiles to G_i/oα subunits. Summary of data obtained from studying coupling between the α_2A adrenergic receptor (A), the D_2S dopaminergic receptor (B) and the M₄ muscarinic receptor (C), and Kir3.1+3.2A channels via the G_iα1, G_iα2, G_iα3, and G_oαA C∏ G mutants. Open bars represent basal currents, and solid bars represent current in response to receptor stimulation. Numbers in parentheses refer to the number of cells recorded from for each experiment. Current density was measured at −100 mV.