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Summary of data from dose-response curves constructed to NECA in the HKIR3.1/3.2/A1 cell lines
| Endogenous | Giα1 C351G | Giα2 C352G | Giα3 C351G | GoαA C351G | |
|---|---|---|---|---|---|
| EC50 | 33.1 nM | 50.7 nM (P = 0.51) | 60.3 nM (P = 0.31) | 59.4 nM (P = 0.51) | 69.2 nM (P = 0.35) |
| Hill coefficient, nH | 0.79 ± 0.27 | 0.64 ± 0.15 (P = 0.64) | 0.5 ± 0.12 (P = 0.3) | 0.9 ± 0.51 (P = 0.85) | 0.82 ± 0.34 (P = 0.95) |
Numbers in brackets refer to level of significance in comparing each exogenously expressed Gi/oα with endogenous G protein.
