Table 6. Contribution (%) of genetic (heritability, h2) and house (c2) effects to variability in malaria and non-malaria clinical and biological phenotypes of P. falciparum (Pf) and P. vivax (Pv).
Phenotype | Acronym | N | Genetic effect | House effect |
h2 (S.E.), p-value | c2 (S.E.), p-value | |||
A. Clinical phenotypes | ||||
Number of visits Pf+ | PFA | 2018 | 12.4 (5.7), 0.009 | 4.6 (2.9), 0.05 a |
Number of non-malaria fever visits | NMF | 2018 | NE, NS | 8.7 (2.9), 7 × 10−4 |
Number of visits Pv+ | PVA | 2018 | 20.8 (3.6), 4.6 × 10−4 | NE, NS |
B. Parasite biological phenotypes | ||||
Pf max parasite density | mx-PFD | 857 | 23.7 (7.9), 1.5 × 10−4 | NE, NS |
Pf parasite densities | PFD | 857 | 20.4 (4.3) | NE, NS |
Pv max parasite density | mx-PVD | 470 | 19.1 (10.5), 0.02 | NE, NS |
Pv parasite densities | PVD | 470 | 14.9 (4.6) | NE, NS |
h2, variance due to genetics, c2, variance due to house effect, S.E. the standard error; NS, not significant (p-value>0.05); NE, not estimated.
Retained because of marginal significance.