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. Author manuscript; available in PMC: 2009 Apr 1.

Published in final edited form as: Exp Neurol. 2007 Dec 15;210(2):549–559. doi: 10.1016/j.expneurol.2007.12.003

Fig 3 — Collagen IV immunostaining (Fig.3a; A-D) and quantification of the Collagen IV staining (Fig. 3b; E, F) in parietal cerebral cortex of adult rats following MCA focal ischemia. PMCAO: permanent middle cerebral artery occlusion (MCAO). Isch: ischemia. R: reperfusion (n = 4). (A) Sham. (B) PMCAO 8 h. (C) Isch 5 h/R 3 h. (D) Isch 5 h/R 3 h + AHA. ^&p < 0.05 compared with Sham group. *p < 0.05 compared with PMCO 8h group. ^#p < 0.05, ^##p < 0.01 compared with Isch 5 h/R 3h group. Reperfusion 3 h after 5 h MCAO accelerated and worsened the injury to the basal lamina relative to PMCAO 8 h in parietal cortex (C, E and F). Administering the MMP inhibitor AHA just before reperfusion (30 min before) decreased the injury (D, E and F).

Fig 3 — Collagen IV immunostaining (Fig.3a; A-D) and quantification of the Collagen IV staining (Fig. 3b; E, F) in parietal cerebral cortex of adult rats following MCA focal ischemia. PMCAO: permanent middle cerebral artery occlusion (MCAO). Isch: ischemia. R: reperfusion (n = 4). (A) Sham. (B) PMCAO 8 h. (C) Isch 5 h/R 3 h. (D) Isch 5 h/R 3 h + AHA. ^&p < 0.05 compared with Sham group. *p < 0.05 compared with PMCO 8h group. ^#p < 0.05, ^##p < 0.01 compared with Isch 5 h/R 3h group. Reperfusion 3 h after 5 h MCAO accelerated and worsened the injury to the basal lamina relative to PMCAO 8 h in parietal cortex (C, E and F). Administering the MMP inhibitor AHA just before reperfusion (30 min before) decreased the injury (D, E and F).