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. 2008 Oct 16;8:299. doi: 10.1186/1471-2407-8-299

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Copyright © 2008 Gelsi-Boyer et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Characterization of RUNX1 mutations in CMML patients. A: Genomic organization of RUNX1 gene at 21q22.12 and RUNX1 protein. Functional (i.e. RUNT and RUNXI [for RUNX Inhibitor domain], as defined by PFAM accession numbers PF00853 and PF08504, respectively) and motifs of the RUNX1 protein were positioned according to the SMART program http://smart.embl-heidelberg.de/. Nucleotide (cDNA level) and deduced aminoacid sequences of the RUNX1 protein are positioned above and below the corresponding protein, respectively. The genomic RUNX1 sequence of CMML 5 exhibited a mutation in the consensus splicing sequence of intron 3. B: Mutations of RUNX1. All mutations but one introduced an aberrant stop codon (cases 3, 6, 12, 15 and 87). Two missense mutations (cases 1 and 25) were also observed. The mutations are located with respect to the modified aminoacid of the RUNX1 protein. C: Representation of putative mutated RUNX1 proteins. According to the SMART program, all putative modified proteins have lost their RUNT and RUNXI domains.