Table 2.
Patient characteristics
| MOSAICa | NSABP C-07b | |||
|---|---|---|---|---|
| Characteristics All patients | FOLFOX (N=1123) | FL (N=1123) | FLOX (N=1200) | FULV (N=1207) |
| Age | ||||
| Median, years | 61 | 60 | 59.0 | 59.0 |
| < 65 years, % | 64.4 | 66.2 | 68.9 | 67.0 |
| Sex, % | ||||
| Male | 56.1 | 52.4 | 55.3 | 57.8 |
| Female | 43.9 | 47.6 | 44.7 | 42.2 |
| T stage, %c | ||||
| T1 | 0.0 | 0.0 | 2.8 | 2.5 |
| T2 | 4.5 | 4.8 | 8.6 | 10.0 |
| T3 | 76.0 | 75.9 | 81.8 | 79.6 |
| T4 | 19.0 | 18.5 | 6.8 | 6.9 |
| Unknown | 0.5 | 0.8 | 0.3 | 0.7 |
| Nodal status, %c | ||||
| 0 (stage II) | 40.2 | 39.9 | 28.8 | 28.8 |
| 1–4 | 44.4 | 45.7 | 52.6 | 51.5 |
| 5+ | 15.1 | 14.2 | 18.0 | 19.5 |
| Unknown | 0.2 | 0.2 | 0.2 | 0.3 |
a
André, T et al. N Eng J Med. 2004, 350:2343–2351.
b
Kuebler, JP et al. J Clin Oncol. 2007, 25:2198–2204.
c
The distribution of positive nodes and T stage are the only patient characteristics significantly different between the two trials (p<0.0001 for each).