Table 4.
Comparison of peripheral sensory neuropathy
| During treatment (%) | Six months after treatment (%) | 4-year follow-up (%) | ||||
|---|---|---|---|---|---|---|
| NCI CTC AEa Grades | FOLFOXb N=1106 | FLOXc N=1189 | FOLFOXb N=1058 | FLOXc N= 1030 | FOLFOXd N=811 | FLOX |
| Grade 0 | 7.9 | 21.3 | 59.0 | 71.4 | 84.3 | NAe |
| Grade 1 | 48.2 | 52.1 | 31.9 | 23.4 | 12.0 | NA |
| Grade 2 | 31.6 | 19.8 | 7.8 | 4.8 | 2.8 | NA |
| Grade 3 | 12.4 | 6.7 | 1.3 | 0.5 | 0.7 | NA |
| Grade 4 | 0.2a | 0a | ||||
a
NSABP C-07 used CTCAE version 2.0, that grades neurosensory from 0–4. MOSAIC used CTCAE version 1.0, which grades neurosensory from 0–3.
b
André, T et al. N Eng J Med. 2004, 350:2343–2351.
c
Unpublished data, Greg Yothers, PhD. (NSABP Biostatistical Center)
d
de Gramont, A et al. J Clin Oncol, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007, (Abstr 4007).
e
NA = Not available.