Fig 2. PARP-1 expression is enhanced with ethanol treatment.
Neurons grown on cover slips were treated with 4mg/ml ethanol for 24 hours. Immunofluorescent staining was done using anti-PARP-1 antibody followed by Cy-3 conjugated rabbit secondary antibody. There is a robust increase in PARP-1 expression in ethanol exposed samples, primarily in the nuclei (Fig. 2A). Fig. 2B is a composite of five random fields. The intensity increase is approximately 10 fold (n=5, *= p<0.0002).