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. 2008 Oct 25;36(21):6835–6847. doi: 10.1093/nar/gkn792

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Ex vivo transfection of dicistronic RNA confirms that the APP mRNA 5′-leader contains an IRES. (A) Dicistronic luciferase RNAs containing the 5′-leader from the β-globin or APP mRNA inserted into the intercistronic region of a dicistronic luciferase construct were individually transfected into C6 cells. (B) Luciferase activity is shown as the ratio of Photinus luciferase to Renilla luciferase (P:R) and is normalized to the activity obtained from the mRNA containing the β-globin 5′-leader.