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. 2008 Oct 29;36(21):6859–6871. doi: 10.1093/nar/gkn802

Figure 4.

Figure 4.

Comparison of the preferred sequence context for cytidine deamination by rabbit A1 in first strand cDNA and the genomic RNA of wild-type orΔvif viruses. (A) TTC*T in the HIV-1 minus-strand cDNA was the preferred tetranucleotide target of rabbit A1. Shown are percentages of each nucleotide found at the −2, −1, +1 and +2 positions relative to the dC residue targeted for deamination (position zero). The consensus DNA sequence is shown at the bottom of each minitable by bold. (B) WC*W sequence in the HIV-1 genome was the preferred RNA target of rabbit A1. Comparison of the preferred sequence observed in the viral genomic RNA produced in the presence of rabbit A1. All of the mutations in HIV-1 genomic RNA aligned with respect to the cytidine (C) targeted for deamination (position zero). The frequency with which each of the four bases found at positions adjacent to the deaminated C is indicated. The consensus RNA sequence is shown at the bottom of each minitable by bold.