Table 3. Clinical Outcomes at 3 Months for Tier 1, Tier 2, and the Overall Trial of Combination Treatment Versus rt-PA–Only Groups.

	Tier 1			Tier 2			Overall
	Combined	Control	P Value	Combined	Control	P Value	Combined	Control	P Value
n	29	11		40	14		69	25
mRS score 0–1 or return to baseline*	9 (31%)	5 (45%)	0.47	12 (30%)	7 (50%)	0.21	21 (30%)	12 (48%)	0.14
Barthel index ≤95*	12 (41%)	8 (73%)	0.16	20 (50%)	10 (71%)	0.22	32 (46%)	18 (72%)	0.04
Glasgow outcome score 0*	13 (45%)	5 (45%)	1.0	15 (38%)	8 (57%)	0.23	28 (41%)	13 (52%)	0.35
Symptomatic ICH	1 (3%)	1 (9%)	0.48	0 (0%)	1 (7%)	0.26	1 (1%)	2 (8%)	0.17
Any ICH	5 (17%)	3 (27%)	0.66	3 (8%)	2 (14%)	0.60	8 (12%)	5 (20%)	0.32
Death at 90 days	8 (28%)	1 (9%)	0.40	7 (18%)	2 (14%)	1.0	15 (22%)	3 (12%)	0.38
Death at 7 days	4 (14%)	1 (9%)	1.0	5 (12%)	0 (0%)	0.31	9 (13%)	1 (4%)	0.28
NIHSS score decrease ≥4 in 24 hours	14 (48%)	6 (54%)	1.0	15 (38%)	5 (36%)	1.0	29 (42%)	11 (44%)	1.0
NIHSS score ≤2 at 24 hours	2 (7%)	1 (9%)	1.0	7 (18%)	4 (29%)	0.45	9 (13%)	5 (20%)	0.51

Data are expressed as n (%); comparisons were made with Fisher's exact test owing to small numbers.

^*Deaths (n=18) and missing (n=4) patients were coded as “bad” outcome.