Table 2.

Associations between leptin and ObR in HER2-positive and HER2-negative breast cancer

		ObR +		ObR -		p-value
		N	%	N	%
All tumors	Leptin +	46	78.0	1	1.7	< 0.001
	Leptin -	3	5.1	9	15.3
		N	%	N	%
HER2	Leptin +	23	74.2	0	0.0	< 0.001
positive	Leptin -	1	3.2	7	22.6
HER2	Leptin +	23	82.1	1	3.6	0.045
negative	Leptin -	2	7.1	2	7.1

The expression of leptin and ObR was assessed by IHC, as described in Materials and Methods. The percentage (%) and actual number (N) of tumors expressing combinations of leptin and ObR is given for all tumors as well as in HER2-positive and -negative subgroups. Associations between leptin and ObR in were evaluated using Fisher's exact test for count data.